INS and diabetes mellitus: Various drugs have been used to induce diabetes mellitus, such as streptozotocin in pancreatic beta cells, which enters through the GLUT-2 transporter, preventing the passage of glucose into the cell β which generates cell damage and a deficit in the expression of proinsulin, generating a state of hyperglycemia and a decrease in body weight within the first 2 to 4 days after induction [13].