Having identified a glutamine (Q) substitution at this 59th position within the RGS12 PDZ domain as associated with “Family 085” of their BD proband genetics study, Forstner and colleagues [10] employed five different predictive tools (current to 2020) in an attempt to ascertain a consensus prediction of the functional significance of this R59Q missense variation, namely, SIFT [48], PolyPhen-2 HumDiv and PolyPhen-2 HumVar [49], likelihood ratio testing (LRT; ref. [50]), and MutationTaster [51]. Here, RGS12 is linked to Behcet disease.