This set of four independent observations of RGS12 missense mutations associated with mental health disorders [10,16,17,18] (summarized in Figure 1A) strongly supports the hypothesis that genetic variation in the RGS12 gene could be causal to developing mental health disorders such as BD or, at least, provide new insight into neurotransmitter signaling (dys)function that might direct future BD treatment effectiveness. This evidence concerns the gene RGS12 and Behcet disease.