For example, proteins such as TDP-43 (primarily associated with ALS), Aβ1-42 (involved in AD), Htt103Q (implicated in Huntington’s disease), and RNQ1 (a prion in budding yeast) all exhibit greater aggregation and toxicity in cells that display error prone transcription compared to WT cells [30]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.