Pancreatic adenocarcinoma upregulated factor (PAUF; also known as ZG16B) is a novel tumor-promoting secreted protein that plays a critical role in metastasis and cancer progression in several types of cancer, such as pancreatic cancer [17], cervical cancer [18], colorectal cancer [19], and ovarian cancer [20]. The gene discussed is ZG16B; the disease is pancreatic neoplasm.