As anticipated, the HBB cluster, BCL11A, and the HBS1L-MYB intergenic region were consistently found to be associated with HbF changes in the included studies across all disease groups (i.e., non-hemoglobinopathy, SCD, β-thalassemia trait), involving a substantial number of SNPs. The gene discussed is HBS1L; the disease is hemoglobinopathy.