Although, in our study, activation of both ileal and hepatic FXR did not correlate with DTscore and DDscore, multiple studies have shown that up-regulation of FXR is beneficial to improve T2DM, increasing hepatic glycogen synthesis and significantly improving hyperglycemia and hyperlipidemia [47,52,63,64]. This evidence concerns the gene NR1H4 and type 2 diabetes mellitus.