Furthermore, Rutin exerts antitumor effects in vivo and in vitro, showing cytotoxic effects, antiproliferative, antimigration, proapoptotic, and morphogenic effects on GL-15 or C6 glioblastomas (GBM) cells, reducing vascular endothelial growth factor secretion in U343 and U118 GBM cells and the formation of tumors in the brain of Wistar rats after 30 days of U-251 GBM cell xenotransplantation [7,8,14,15,16]. Here, VEGFA is linked to glioblastoma.