MYD88 (66.2%), CD79B (50.0%), PIM1 (92.5%), HLA-B (73.8%), BTG1 (70.0%), CDKN2A (62.0%), ETV6 (55.0%), SPIB (51.9%), OSBPL10 (51.2%), TOX (48.1%), BCL2 (48.1%), BTG2 (43.8%), MPEG1 (43.8%), HLA-A (43.0%), HLA-C (42.5%), SETD1B (41.8%), KLHL14 (41.2%), TBL1XR1 (35.0%), GRHPR (33.8%), PRDM1 (32.5%), CD58 (31.6%), TAP1 (26.6%), PIM2 (25.0%), FOXC1 (21.2%), IRF4 (20.0%); encompasses the majority of observed primary CNS lymphomas and primary testicular lymphomas. The gene discussed is MYD88; the disease is primary central nervous system lymphoma.