WHO-HAEM5 separates DLBCL/HGBCL with MYC and BCL2 rearrangements from the previous entity—HGBCL with MYC and BCL2 and/or BCL6 rearrangements, also known as “double-hit”/“triple-hit” (DH/TH) lymphomas [9]. This evidence concerns the gene BCL2 and lymphoma.