NFKB1 and diffuse large B-cell lymphoma: In an exciting article, recurrent focal deletions of the chr14q32.31-32 locus, correlating with reduced TRAF3 expression in 24/324 dnDLBCL cases, were revealed; furthermore, TRAF3 loss was associated with enhanced non-canonical NF-κB signaling in primary DLBCL and, also, TRAF-3-deficient DLBCL cells require NF-κB kinase (NIK) for growth and survival.