Although it was GCB-DLBCL that was first associated with inactivating mutations and, thus, loss of sphingosine 1-phosphate (S1P) receptor-2 (S1PR2), S1PR2 was identified as a tumor suppressor transcriptionally silenced by forkhead box protein 1 (FOXP1) in the aggressive ABC subtype [67]. This evidence concerns the gene S1PR2 and diffuse large B-cell lymphoma.