The pieces of the Notch puzzle in B-cell lymphoma are slowly appearing in the literature; for example, in DLBCL, Notch signaling mediates M2 polarization of tumor-associated macrophages (TAMs) through the CREBBP/EP300-FBXW7-Notch-CCL2/CSF1 pathway [122]. This evidence concerns the gene CREBBP and diffuse large B-cell lymphoma.