CCN2 and colorectal carcinoma: We created a spheroid platform that is deficient in connective tissue growth factor (CTGF)/cellular communication network factor 2 (CCN2), a critical negative regulator of Wnt signaling, which is closely related to the onset and progression of CRC and regulates cancer stemness by mediating inflammatory response and modulation of epithelial-to-mesenchymal transition (EMT) (2).