Further studies in this direction might include proteomic profiling of the secretome collected from the ECs exposed to other endothelial dysfunction triggers (e.g., high glucose, urea, lipopolysaccharide, pro-inflammatory cytokines, toxic chemicals, or fatty acids) to show whether soluble CD59 is overexpressed and basement membrane proteins are downregulated in their cell culture supernatant as well. Here, CD59 is linked to endothelial dysfunction.