The glycation of CD59 (presumably its Lys41/His44 motif [58]) leads to its inactivation and results in its inability to perform protection against complement-dependent lysis, explaining the deposition of the membrane attack complex on blood vessels [59] and red blood cells [60] and subsequent vascular injury in target organs (such as the kidneys and nerves) [59] and haemolytic anemia [60] in patients with diabetes. Here, CD59 is linked to diabetes mellitus.