Strikingly, CD59-deficient hyperlipidemic mice were characterised by endothelial injury, accelerated atherosclerosis, higher plaque burden, and co-localisation of the membrane attack complex with atherosclerotic lesions [64,65,66,67,68,69], whilst CD59 overexpression or complement inhibition attenuated plaque development [65]. Here, CD59 is linked to atherosclerosis.