CCL4 and pachyonychia congenita: We were able to show that the serum of exercise-trained patients with advanced-stage pancreatic cancer (PC) leads to the release of certain myokines, such as C-X-C motif ligand 1 (CXCL1), Interleukin 10 (IL10), and C-C motif chemokine ligand 4 (CCL4), from contracting skeletal muscle.