Wfdc3 encodes a member of the WAP-type four-disulfide core (WFDC) domain family, which functions as a protease inhibitor, promoting the ERβ-mediated transcriptional repression of TGFBR1 in colorectal cancer [43], thus showing a link between WFDC3 and oestrogen receptor. The gene discussed is TGFBR1; the disease is colorectal cancer.