Furthermore, another murine study involving cecal ligation and puncture (CLP) to induce polymicrobial sepsis demonstrated that administration of pioglitazone 1, 4, and 18 h before CLP resulted in increased IL-10 levels in the peritoneal fluid of treated animals, along with inhibition of inflammation via the Myd88 pathway [109]. The gene discussed is MYD88; the disease is Sepsis.