A study on the induction of acute pancreatitis with lipopolysaccharide and caerulein, aimed at developing acute lung injury in a mouse model, observed that treatment with sitagliptin, a linagliptin analog, reduced ROS via stimulation of the p62–Keap1–Nrf2 signaling pathway and its synthesis products such as HO-1 [116]. Here, KEAP1 is linked to acute pancreatitis.