GEM and pachyonychia congenita: To determine if the combination of PhAs-LHP and Gem suppressed PC growth in vivo more effectively than either compound singly, human PC cells (MiaPaCa-2) were subcutaneously injected into the flanks of Scid mice, which were then treated with Gem alone (50 mg/kg) or with gemcitabine (50 mg/kg) plus PAO (50 μg/kg) or PhAs-LHP (200 μg/kg) by intraperitoneal injection as described in the Materials and Methods section.