An inhibitor of HSP90AA1 was reported to remarkably induce apoptosis and suppress cell proliferation in lung cancer through an ERK/AKT-dependent mechanism [34] and to induce autophagic cell death in osteosarcoma by suppressing AKT/mTOR signaling [37], highlighting its importance in cancer biology. The gene discussed is HSP90AA1; the disease is osteosarcoma.