The data suggested that the molecular targets of AE in NSCLC were associated with signal transduction, receptor tyrosine kinase signaling, extracellular matrix degradation, regulation of transcription of cell cycle genes by p53, MAPK family signaling cascades, apoptosis, cell cycle, and PI3K/AKT signaling in cancer (Table 1). This evidence concerns the gene AKT1 and non-small cell lung carcinoma.