Scg2, part of the chromogranin-secretogranin family [25], has been implicated in autoimmunity, particularly in the recognition of autoantigens by CD8+ T cells; this suggests it may have a potential role in autoimmune reactions against pancreatic beta cells, as indicated by research into peptides derived from Scg2 [26]. The gene discussed is CD8A; the disease is Autoimmunity.