Given the importance of the MAdCAM-1/α4β7 integrin pathway in the migration of T cells to pan-LNs and inflamed pancreas in mouse models of T1D, it warrants testing the therapeutic efficacy of humanized MAdCAM-1 mAbs in a humanized model or a clinical trial for T1D. This evidence concerns the gene MADCAM1 and type 1 diabetes mellitus.