Thus, the suppression of T1D by temporary blockage of MAdCAM-1 in NOD mice may be mediated by inhibiting the migration of lymphocytes into pan-LNs and inflamed islets, increasing Tregs in inflamed islets and potentially impairing hematopoietic stem cell migration to bone marrow. The gene discussed is MADCAM1; the disease is type 1 diabetes mellitus.