VEGFA and neoplasm: Our results are consistent with the observations made by Rohr-Udilova et al. [17], who found that decreasing Se levels, causing excessive lipid peroxides, would activate the transcription factor activator protein 1, which regulates angiogenesis and inflammation pathway, to increase vascular endothelial growth factor and interleukin -8, thus promoting HCC tumor progression in vitro, in vivo, and clinical research.