TGFB1 and renal fibrosis: This study further revealed the regulatory relationship between PDK 1, HIF-1α and the TGF-β1/Smad signaling pathways in hypoxia acclimation, at high altitudes, providing basic information for the prevention and treatment of renal fibrosis induced by hypoxia, but the mechanism underlying the blocking of hypoxia-induced renal fibrosis still needs further research.