This study revealed that the mechanism behind bromelain’s tumor-suppressing effect involves the activation of p53, alterations in the Bax/Bcl-2 balance favoring apoptosis, the activation of caspase enzymes, a reduction in Cox-2 enzyme levels, and the obstruction of the NFκB signaling pathway through modulation of the MAPK and Akt/PKB pathways [17,18]. This evidence concerns the gene AKT1 and neoplasm.