Fasting glucose and insulin and HOMA-IR were used to measure IR. The 12-month prevalence of depressive disorder was 5.4% among men and 11.7% among women. It was found that the insulin resistance was higher in depressive individuals (17.2% (95% CI 0.7–36.0%, p = 0.04) higher in men and 11.4% (1.5–22.0%, p = 0.02) higher in women). Overall insulin resistance was associated with a depressive disorder at 13.2% (−3.1 to 32.3%, p = 0.12) in men and 6.1% (−4.1 to 17.4%, p = 0.25) in women. The gene discussed is INS; the disease is depressive disorder.