IL6 and septic shock: Anyhow, the only large RCT regarding CS treatment found a substantial decrease in IL-6 after a CS treatment of six hours per day for up to seven consecutive days in adult patients with septic shock and ARDS, but the decrease did not differ compared to controls; on the other hand, CS treatment was initiated within 72 h of established sepsis or septic shock and acute lung injury or ARDS [9].