PROS1 and hyperinsulinemic hypoglycemia, familial, 4: This included genetic thrombophilia due to Leiden mutation, protein C and/or protein S deficiency, antithrombin (AT)III deficiency, methylenetetrahydrofolate reductase (MTHFR) mutations, as well as acquired thrombophilia (antiphospholipid syndrome, lupus anticoagulant).