Regarding gonadal function, at baseline, 26/118 (22.0%) patients had hypogonadism, including both the overt (low TT or cFT, independently from gonadotropin levels, 13/26 = 50%) and compensated forms (high LH with normal TT and cFT levels, 13/26 = 50%). The gene discussed is PLOD1; the disease is hypogonadism.