Certainly, the genetic differences between juvenile melanomas and adult melanomas (BRAF more frequent in the former, NRAS, NF-1 and TP53 in the latter) associated with differences in the anatomical localizations of primary melanomas (intermittent sun-exposed areas in juvenile melanomas and chronically sun-exposed areas in adult and elderly patients) conceal physio-pathological mechanisms that could also be relevant for the setting of a different follow-up and therapeutic approach in the future. This evidence concerns the gene NF1 and melanoma.