CD8A and peripheral arterial disease: The role of immune cells, particularly monocytes and T cells, in the context of peripheral arterial disease (PAD) has been the focus of extensive research by Pawel Maga et al. [41,42] In a study of 45 patients with Rutherford 3–4 PAD undergoing percutaneous transluminal angioplasty (PTA), the author observed an acute reduction in CD8+ T cell subsets immediately following the procedure.