Prior data suggested that hepatic factors such as Angiopoietin-Like Protein 4 (ANGPTL4), Angiopoietin-Like Protein 6, FGF21 (Fibroblast-growth factor 21), and Insulin-Like Growth Factor (IGF-1) may play a role in preventing AKI [24]. The gene discussed is ANGPTL4; the disease is acute kidney injury.