GLP1R and obesity due to melanocortin 4 receptor deficiency: In the study by Wu et al., the past medical history and comorbidities of the one patient in the GLP-1 RA group who aspirated was a 42-year-old man with obesity (BMI 37), prior history of Barrett’s esophagus on PPI and histamine receptor agonist, OSA on CPAP, mixed anxiety and depressive disorder on medications with anticholinergic effects (paroxetine), and prior history of lung abscess likely secondary to aspiration in the setting of heavy alcohol use (now sober for 4 years), who had fasted for more than 18 h, with the last dose of GLP-1 RA and gastrointestinal symptoms not reported.