The NF-κB-mediated pathway directly participates in the activation of the NLRP3 family (which encodes NOD—nucleotide-binding oligomerization domain, LRR—leucine-rich repeat, and pyrin domain-containing protein 3) and the accompanying inflammasome, being involved in the advancement of insulin resistance associated with obesity and diabetes [50,51,52]. This evidence concerns the gene NFKB1 and Obesity.