Being inversely correlated with obesity and visceral adiposity, adiponectin supports interleukin 10 (IL-10) expression and inhibits the nuclear factor kappa light-chain-enhancer of activated B cells (NFκB), influencing interferon gamma (IFNγ) production in monocyte-derived cells [39]. The gene discussed is IFNG; the disease is obesity due to melanocortin 4 receptor deficiency.