Therefore, SNPs of the genetic locus 9p21.3, particularly rs564398 of the ANRIL gene, involved in the balance of cellular functions (cell cycle control, proliferation), may contribute to the development of CAD in the context of T2DM and represent potential for further exploration of their application in early diagnostics and managing diabetes. The gene discussed is CDKN2B-AS1; the disease is type 2 diabetes mellitus.