GJA1 and atrial fibrillation: Similarly, as exhibited in Figure 6B, SOX4 (simulating the physiological state of a healthy person) and Trp97* (simulating the pathological condition of an AF patient with a homozygous SOX4 mutation of Trp97*) transactivated the GJA1 promoter by ~12-fold and ~1-fold, respectively (SOX4 versus Trp97*: t = 10.8912; p = 0.0004).