CD8A and neoplasm: The profound increase in tumor-infiltrating CD8+ T cells could be at least partially attributed to a simultaneous reduction in MDSCs in 4T1 tumors treated with CBL0137 HAI as reflected in the favorable MDSC/CD8+ T cell ratios [ratio of 14.7:1 (vehicle) to 2.2:1 (CBL0137)] (Figure 6D).