Remarkably, both TRBP2 and PACT proteins were, herein, in silico shown to interact with the DICER protein, regardless of the examined sub-cellular compartment (cytoplasm versus nucleus), in Goiter multinodular 1, Rhabdomyosarcoma, embryonal, 2 and Wilms tumor diseases being related to DICER1 syndrome [93,94,95,96], while they also interact with the AGO2 protein in Lessel–Kreienkamp syndrome (although in distinct sub-cellular compartments), a neuro-developmental disorder related to AGO2 gene mutations [97]. This evidence concerns the gene PRKRA and DICER1-related tumor predisposition.