TARBP2 and osteosarcoma: Remarkably, besides its fundamental contribution to the operation of RNAi machinery, TRBP2 has been recently implicated in the critical orchestration of miRNA/RNAi-independent processes, including, among others, (a) osteosarcoma-cell proliferation and invasion [45], (b) hepatocellular-carcinoma progression [46], and (c) gastric cancer growth and metastasis [47], thus rendering TRBP2 a major determinant of the malignant phenotype.