Given the pivotal role of KIF2A in mitotic-spindle formation and normal spindle dynamics during mitosis [90,92], together with the involvement of IQGAP2 in the regulation of cell morphology and motility and cancer development [91], the presumed interactions of TRBP2 with KIF2A and IQGAP2 proteins further support our current molecular model for the negative control of TRBP2 on KIF2A and IQGAP2 activities during cell division and specific stages of tumor initiation, progression, and metastasis. The gene discussed is KIF2A; the disease is cancer.