NEDD8 and cancer: The NEDDylation pathway uses the Ubiquitin-like protein NEDD8, which is essential for the enzymatic activity of a subclass of Ubiquitin E3 Ligases (mediate for the movement of Ubiquitin from its carrier to the protein substrate) with NEDDylation enabling Ubiquitination and degradation rates of proteins, several of which have been found to control either normal cellular function or cancer cell development [84,85].