To further expand and strengthen our rationale, we next analyzed the TRBP2 protein-expression profiles in pre-metastatic (WM115) and metastatic (WM266-4) human melanoma cells, both having been derived from the same patient (thus, excluding a plethora of genetic variations, polymorphisms, and metastasis-irrelevant mutations). This evidence concerns the gene TARBP2 and melanoma.