EIF2AK2 and Leukoencephalopathy: Furthermore, a PACT molecular interactome was detected in the cytoplasm, but not in the nucleus, of Leukoencephalopathy (disease) cells (Supplementary Figure S8), with the assembly of the PACT-PKR complex justifying the capacity of PACT to activate PKR protein kinase, as previously reported, specifically in the cytoplasm, during cell division.