Since WM115 and WM266-4 human melanoma cell lines are both characterized by the lack of TRBP2 detection in all mitotic cells and by the simultaneous TRBP2 presence in all interphase-cell nuclei examined (Figure 5), metastasis-dependent mechanisms must play non-essential or dispensable/redundant, roles in mitosis-specific TRBP2 elimination in human melanoma (and urothelial bladder carcinoma; Figure 3) settings. This evidence concerns the gene TARBP2 and melanoma.