TP53 and colonic neoplasm: To further examine our argument in a setting that, besides a TP53-detrimental deletion, does not contain additional genetic lesions, we next used the human colon cancer cell line HCT116-p53−/− that lacks TP53-gene activity to check TRBP2-expression profile during mitosis in the absence of p53 protein, with the parental HCT116-p53+/+ counterpart colon cancer cells that express the wild-type p53-protein form being used as suitable control.