This is also the case for Dystonia 16, a disorder caused by PACT/PRKRA gene mutations [98], with TRBP2 losing its ability to interact with PACT in the cytoplasm (retained in the nucleus) but with PACT gaining several interactors, including TRBP2, both in the cytoplasm and the nucleus as well. The gene discussed is TARBP2; the disease is dystonia 16.