COX17 and colorectal carcinoma: Additionally, other copper chaperones, such as SCO1 (Synthesis of Cytochrome C Oxidase 1), SLC31A1 (Solute Carrier Family 31 Member 1), and COX11 (Cytochrome C Oxidase Copper Chaperone), may contribute to increased copper influx into the tumor, which is necessary for CRC growth [68].