Again, most of the genes were related to bone remodeling (BGN, COL1A1, COL3A1, FBLN5, LUM, SULF1), potentially explaining PCa osteotropism to immune-related pathways (C1Q; C1QB, C1QC, C1R, C1S, HLA-DRB1), and Wnt signaling (SFRP2, SFRP4). Here, BGN is linked to posterior cortical atrophy.