When mean expression of PTPRZ1, ITGB4, UCHL1, HIF1A were evaluated together to assess the prognostic value of the integrin α6β4-UCHL1-HIF1A-PTPRZ1 axis in breast cancer, we found that, compared to the low expression group, high expression of these four genes associated with worse OS (HR = 1.72, Figure 7A), DMFS (HR = 1.43, Figure 7B), PPS (HR = 1.76, Figure 7C) and RFS (HR = 1.47, Figure 7D) for breast cancer patients with higher HR than HIF1A alone in all measures except PPS. The gene discussed is PTPRZ1; the disease is breast cancer.