Significantly worse CSS was observed in patients with a lack of resolution in anemia (Hgb HR 3.34; Hct HR 3.14; p < 0.001), hypercalcemia (HR 5.16, p < 0.001), elevated CRP (HR 2.58, p < 0.001), elevated ESR (HR 3.31, p < 0.001), and elevated LFTs (HR 2.12, p = 0.018). This evidence concerns the gene CRP and hypercalcemia disease.