In diagnostic histopathology, SOX10 immunostaining proves to be a valuable diagnostic tool, due to its high sensitivity in identifying melanocytic and peripheral nerve sheath neoplasms in a variety of neoplasms, including cutaneous adnexal neoplasms, salivary gland neoplasms, breast neoplasms, melanocytic lesions, and peripheral nerve sheath tumors [122]. This evidence concerns the gene SOX10 and epidermal appendage tumor.