MGMT and neoplasm: In particular, Rammohan et al. presented an FA-derived composite white-matter score which showed prognostic significance in MGMT-unmethylated glioblastoma [39] and Taylor et al. examined the core–shell ratio (length of tracts within the “necrotic core” of the tumor compared to the length of the tracts which circumscribe the mass at its visible margin) [40].