TYK2 and colorectal carcinoma: No significant differences in the methylation status (Table 2) or TYK2 mRNA expression level (p = 0,3955, paired t test, CRC: 3.258 ± 2.343, healthy margins: 4.417 ± 3.417) were found between samples representing paired CRC and healthy intestinal mucosa tissues (Figure 4H).