For the survival analysis of the tissue microarray CCA dataset, ITIH5 expression was dichotomized into low to moderate (IRS of 0 to 8) and high expression (IRS of 8 to 12) groups, as shown in Figure 2A. Patients with strong ITIH5 expression were characterized by a longer overall survival (log rank p = 0.0385 *). The gene discussed is ITIH5; the disease is cholangiocarcinoma.