Transferring this mechanism to CCA, one might expect an opposite starting position and course of events and thus high ITIH5 promoter DNA methylation in normal tissue where ITIH5 expression is low (and possibly epigenetically silenced) and a reduced or completely lost ITIH5 promoter DNA methylation in CCA tumor tissue where ITIH5 mRNA and protein are strongly expressed. The gene discussed is ITIH5; the disease is cholangiocarcinoma.