Numerous studies in the last 15 years have shown that the well-characterized tumor suppressor gene ITIH5 is epigenetically silenced, and thus, ITIH5 transcription is considerably downregulated in many tumor entities [16,18,19,22,25,26], while forced re-expression in tumor cell lines has demonstrated strong tumor suppressive effects, like a reduction in proliferation and the migration and invasion of cells [16,19,25]. This evidence concerns the gene ITIH5 and neoplasm.