PTEN and glioblastoma: For example, Ma et al. identified a mechanism of resistance to ionizing radiation therapy in glioblastomas with FGFR2-mediated phosphorylation of PTEN on tyrosine 240 (pY240-PTEN) and found that blocking Y240 phosphorylation increased sensitivity to radiation and extended survival in mouse models, which could be a therapeutic approach to study further [160].