IDH2 and neoplasm: Izquierdo et al. tried to characterize a series of IDH-wildtype, TERT-promoter mutant tumors with MRI, but results showed no radiological association with histological grade, EGFR amplification, MGMT methylation, or chromosome 7 gain and chromosome 10 loss [55], and even the radiological features they observed, like tumor infiltration, enhancement and localization, are difficult to extrapolate to bigger cohorts.