For example, local injection of adeno-associated viruses expressing an sgRNA-guided and catalytically impaired Campylobacter jejuni CRISPR-associated protein 9-fused adenine base editor (CjABE) reverts TERTp mutation, reducing TERT transcription and TERT protein expression and subsequently inhibiting glioma growth [113]. This evidence concerns the gene TERT and central nervous system cancer.