IDH2 and astrocytoma (excluding glioblastoma): Glioblastoma, IDH-wildtype grade 4 astrocytoma is included as one of the three types of adult-type diffuse glioma listed in the WHO CNS5 classification, with the other two being astrocytoma with IDH-mutant and oligodendroglioma with IDH-mutant and 1p/19q-codeleted [6].