MGMT and glioblastoma: A phase I clinical trial (NCT01700569, https://clinicaltrials.gov/study/NCT01700569, accessed on 27 October 2024) carried out in France evaluated the safety and efficacy of administering folic acid combined with temozolomide and radiotherapy in unmethylated MGMT promoter glioblastoma patients, with folate acting as a methyl donor and increasing DNA methylation.