PTEN and glioblastoma: Nan et al. showed that the combination of an adenovirus-mediated PTEN plus PI3K inhibitor LY294002 suppressed cell proliferation, arrested the cell cycle, reduced cell invasion and synergistically promoted cell apoptosis in in vitro and in vivo xenograft glioblastoma mouse models by effectively inhibiting the PI3K/AKT pathway, a promising result that warrants further investigation gene therapy [161].