MTOR and glioblastoma: The loss of chromosome 10 can be seen in up to 80% of glioblastoma cases [149] and is commonly linked to the inactivation of phosphatase and tensin homolog (PTEN), a tumor suppressor gene located on 10q23 that inhibits the transduction of growth factor signals through the PI3K/AKT/mTOR pathway; regulates cell migration; and, more importantly, triggers apoptosis, blocking tumorigenesis [56].