ADGRE2 and acute myeloid leukemia: More recently, in an attempt to bypass these limitations, Haubner et al. have explored the profile of expression of membrane antigens on the leukemic blasts of 39 patients with R/R AML and observed that one of the top candidates with high expression in normal hematopoietic tissue and other tissues is the adhesion G protein-coupled receptor ADGRE2; the level of ADGRE2 expression on AML blasts correlates with a poor molecular risk profile and represents an independent prognostic factor [135].