Seemingly, a higher number of early memory cells may underline the existence of an immune system with the potential of generating a leukemia-specific T cell response, while a higher number of terminally differentiated, senescence-like CD8+ T cells may underline a prior chronic response to AML-specific antigens to generate a T cell-mediated antileukemia response [145]. This evidence concerns the gene CD8A and acute myeloid leukemia.