MUTYH and colorectal carcinoma: In particular, the index case of family 6 (Figure 2, III:9), who was compound heterozygous for the c.325C>T (p.Arg109Trp) and c.1187G>A (p.Gly396Asp) MUTYH PVs, developed between 10 and 19 colorectal adenomatous polyps at 46 years of age without a personal or family history of CRC (Figure 2).