APC and Familial adenomatous polyposis: In family 1, a heterozygous APC PV (c.225dupT, p.Asn76Ter) was identified in a female patient who developed between 10 and 19 colorectal adenomatous polyps and CRC at 59 years of age, in the absence of a family history of CPs, CRC, or FAP-associated malignancy.