According to current guidelines from the National Comprehensive Cancer Network (NCCN), genetic testing for high-risk genes associated with hereditary polyposis syndromes (APC, MUTYH) is recommended in individuals with 20 or more colorectal adenomatous polyps and/or a known familial PV in these genes and/or a family history of polyposis, while it may be considered in individuals with 10–19 colorectal adenomatous polyps, desmoid tumor, hepatoblastoma, or individuals who meet the criteria for serrated polyposis syndromes (more than five serrated polyps) with at least some adenomatous polyps. The gene discussed is APC; the disease is polyposis.