The germline PVs involving the well-known genes (APC, BMPR1A, MUTYH, PTEN, SMAD4, and STK11) impact several signaling pathways (Wnt signaling, TGF-β signaling, DNA repair signaling, and the PI3K/AKT pathway) that modulate the carcinogenesis processes of CRC [11]. This evidence concerns the gene APC and colorectal carcinoma.