Inhibits cell viability; disrupts mitochondrial function and suppresses tumor growth by targeting the JAK2/STAT3 signaling pathway; induced the death receptor (DR)4 and DR5 expression level with the generation of reactive oxygen species and the upregulation of CHOP protein expression; promising therapeutic agent for the treatment of oral cancer [257]. This evidence concerns the gene TNFRSF10B and lip and oral cavity carcinoma.