CTTN, FOLR3, ORAOV1, ORAOV1, PPFIA1 and RNF121 genes with poor prognosis in oral verrucous hyperplasia regions with copy number variation: 1p35, 1p36, 11q13, 6p21, 14q22 and 22q12; Most investigated markers: p53, Ki-67, cyclin-B1, cyclin-D1, p21, p27; 8 genes may determine the differences in identity of OVC two OSCC cancers (ADAMTS12, COL4A1, COL4A2, INHBA, MMP1, SERPINE1, TGFBI, HLF). The gene discussed is LTO1; the disease is cancer.