TCF4 and lip and oral cavity carcinoma: Decreases the Wnt signaling transducers such as β-catenin and TCF-4 increased GSK-3α/β, a β-catenin degradation promoting kinase. Consequently, the protein products of β-catenin downstream genes such as c-Myc and Cyclin D1 were downregulated; CD44, was also inhibited; promising candidate for targeted oral cancer therapy [262].