RET and acute myeloid leukemia: RET is activated in AML cells; RET-mTORC1 signaling promotes AML through autophagy suppression [101].○Autophagy induction through RET inhibition was proposed as a therapeutic strategy against AML.○Caution is needed regarding the therapeutic potential of RET, as autophagy may have opposing roles in oncogenesis, depending on the context.In MLL-AF9 translocated AML models, RET was identified, in vitro and in vivo, to be a potential therapeutic target [102].