Considering these findings from previous reports and our present study, RHAMM can also be considered an important target molecule to overcome the chemoresistance of breast cancer, while degradation of intratumoral HA using PEGylated (polyethylene glycol-attached) recombinant human hyalronidase (PEGPH20) is already considered a potent therapeutic strategy of human cancers [33,34]. This evidence concerns the gene HMMR and cancer.