Stromal cells enhance the immune-evasive phenotype of CLL cells by increasing PD-L1 expression through the Notch signaling pathway—myelocytomatosis oncogene—an enhancer of the zeste homolog 2 (Notch–c-Myc–EZH2) signaling axis and by upregulating protein kinase C (PKC)-βII, which activates NFκB, crucial for malignant B cell survival [87,88]. The gene discussed is NFKB1; the disease is B-cell chronic lymphocytic leukemia.