In the context of skeletal muscle, fat adiposity, and metabolic health, although the studies selected for this review were limited in number and heterogeneous regarding dosage and treatment modalities, bergamot extracts appear to improve the metabolic activity in skeletal muscles by increasing glucose uptake and insulin sensitivity, which could contribute to a reduced risk of insulin resistance and metabolic syndrome, often associated with better clinical outcomes in osteosarcopenic obesity [22,23]. The gene discussed is INS; the disease is metabolic syndrome.