Studies have found that USP10 acts as a deubiquitinase of Sirt6 to induce cardiomyocyte hypertrophy and trigger cardiac hypertrophy, and cardiac fibroblasts could aggravate myocardial ischemia–reperfusion fibrosis by enhancing USP10‐dependent Smad4 deubiquitination. Here, USP10 is linked to cardiac hypertrophy.