Studies have found that USP10 acts as a deubiquitinase of Sirt6 to induce cardiomyocyte hypertrophy and trigger cardiac hypertrophy, and cardiac fibroblasts could aggravate myocardial ischemia–reperfusion fibrosis by enhancing USP10‐dependent Smad4 deubiquitination. The gene discussed is USP10; the disease is myocardial ischemia.